[PDF] FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphoma. | Semantic Scholar (2025)

Skip to search formSkip to main contentSkip to account menu

Semantic ScholarSemantic Scholar's Logo
@article{Hutchings2006FDGPETAT, title={FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphoma.}, author={Martin Hutchings and Annika Loft and Mads Hansen and Lars M{\o}ller Pedersen and Thora Buhl and Jesper Jurlander and Simon Buus and Susanne Keiding and Francesco d'Amore and Anne Marie Boesen and Anne Kiil Berthelsen and Lena Specht}, journal={Blood}, year={2006}, volume={107 1}, pages={ 52-9 }, url={https://api.semanticscholar.org/CorpusID:10511914}}
  • M. Hutchings, A. Loft, L. Specht
  • Published in Blood 2006
  • Medicine

For prediction of PFS, interim FDG-PET was as accurate after two cycles as later during treatment and superior to computerized tomography (CT) at all times and in regression analyses, early interimFDG- PET was stronger than established prognostic factors.

731 Citations

Highly Influential Citations

18

Background Citations

145

Methods Citations

43

Results Citations

33

Figures and Tables from this paper

  • table 1
  • figure 1
  • figure 2
  • table 2
  • figure 3
  • table 3
  • figure 4
  • table 4
  • figure 5
  • table 5
  • figure 6

731 Citations

18F-FDG PET After 2 Cycles of ABVD Predicts Event-Free Survival in Early and Advanced Hodgkin Lymphoma
    J. CerciL. F. Pracchia J. C. Meneghetti

    Medicine

    The Journal of Nuclear Medicine

  • 2010

A negative interim 18F-FDG PET result is highly predictive of treatment success in overall HL patients, as well as in subgroups of patients with early or advanced-stage disease and with low or high IPS risk.

  • 141
  • PDF
In vivo treatment sensitivity testing with positron emission tomography/computed tomography after one cycle of chemotherapy for Hodgkin lymphoma.
    M. HutchingsL. Kostakoglu M. Coleman

    Medicine

    Journal of clinical oncology : official journal…

  • 2014

PET after one cycle of chemotherapy is highly prognostic in HL, and in the absence of precise pretherapeutic predictive markers, PET1 is the best method for response-adapted strategies designed to select patients for less intensive treatment.

  • 78
  • PDF
Decisional Early Interim 18F-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography after Two Cycles of Chemotherapy in de novo Hodgkin Lymphoma
    Aurore IltisV. EderH. BlascoP. ColombatD. Sénécal

    Medicine

    Acta Haematologica

  • 2014

It is suggested that salvage therapy for non-responder Hodgkin lymphoma using interim FDG-PET could improve the PFS of this group of patients.

  • 2
Prognostic value of FDG-PET scan imaging in lymphoma patients undergoing autologous stem cell transplantation
    J. SvobodaC. Andreadis S. Schuster

    Medicine

    Bone Marrow Transplantation

  • 2006

A retrospective analysis of 50 lymphoma patients who had an 18F-fluoro-deoxyglucose positron emission tomography scan after at least two cycles of salvage chemotherapy and before autologous stem cell transplantation (ASCT) indicated an extremely poor chance of durable response after ASCT.

  • 86
  • PDF
Interim PET After Two ABVD Cycles in Early-Stage Hodgkin Lymphoma: Outcomes Following the Continuation of Chemotherapy Plus Radiotherapy.
    G. SimontacchiA. Filippi U. Ricardi

    Medicine

    International journal of radiation oncology…

  • 2015
  • 31
FDG-PET/CT predicts outcome in patients with aggressive non-Hodgkin’s lymphoma and Hodgkin’s disease
    S. QuerellouF. Valette O. Couturier

    Medicine

    Annals of Hematology

  • 2006

FDG-PET at mid-treatment can predict the outcome of patients with aggressive lymphoma and should be a useful tool to modify an ineffective therapy.

  • 59
Risk-adapted dose-dense immunochemotherapy determined by interim FDG-PET in Advanced-stage diffuse large B-Cell lymphoma.
    C. MoskowitzH. Schöder A. Zelenetz

    Medicine

    Journal of clinical oncology : official journal…

  • 2010

Interim or post-treatment FDG-PET evaluation did not predict outcome with this dose-dense, sequential immunochemotherapy program, and outside of a clinical trial, it is recommended to recommend biopsy confirmation of an abnormal interim FDg-PET scan before changing therapy.

  • 313
  • PDF
FDG-PET for assessment of early treatment response after four cycles of chemotherapy in patients with advanced-stage Hodgkin's lymphoma has a high negative predictive value.
    J. MarkováC. Kobe Tomas Kozak

    Medicine

    Annals of oncology : official journal of the…

  • 2009

A very good negative predictive value of PET-4 in advanced-stage HL patients treated with BEACOPP is indicated, while there was no progression or relapse in PET- 4-negative patients.

  • 60
  • PDF
Impact of positive positron emission tomography on prediction of freedom from progression after Stanford V chemotherapy in Hodgkin's disease.
    R. AdvaniL. Maeda S. Horning

    Medicine

    Journal of clinical oncology : official journal…

  • 2007

PET status after chemotherapy is strongly predictive of FFP with the Stanford V regimen despite the use of consolidative radiotherapy, and these results have implications for the design of clinical trials adapted to functional imaging.

  • 48
  • PDF
The prognostic value of 18F-FDG PET-CT in the management of Hodgkin's lymphoma: preliminary results of a prospective study.
    R. PaoliniL. Rampin D. Rubello

    Medicine

    Nuclear medicine review. Central & Eastern Europe

  • 2007

The preliminary data of the present study confirm those of previous published studies about the negative predictive value of (18)F-FDG-PET/CT performed after four and six chemotherapy cycles, which contributed to the decision to stop treatment and to avoid radiotherapy in HL patients.

  • 7

...

...

49 References

Prognostic value of interim FDG-PET after two or three cycles of chemotherapy in Hodgkin lymphoma.
    M. HutchingsN. MikhaeelP. FieldsT. NunanA. Timothy

    Medicine

    Annals of oncology : official journal of the…

  • 2005

Early interimFDG-PET is an accurate and independent predictor of PFS and OS in HL and a positive interim FDG- PET is highly predictive of relapse in advanced-stage disease.

  • 336
  • PDF
FDG-PET after two to three cycles of chemotherapy predicts progression-free and overall survival in high-grade non-Hodgkin lymphoma.
    N. MikhaeelM. HutchingsP. FieldsM. O'DohertyA. Timothy

    Medicine

    Annals of oncology : official journal of the…

  • 2005

An early assessment of chemotherapy response with FDG-PET could provide the basis for selection of patients for alternative therapeutic strategies and be an accurate and independent predictor of PFS and OS.

  • 409
  • PDF
PET predicts prognosis after 1 cycle of chemotherapy in aggressive lymphoma and Hodgkin's disease.
    L. KostakogluM. ColemanJ. LeonardI. KujiHolly ZoeS. Goldsmith

    Medicine

    Journal of nuclear medicine : official…

  • 2002

F-FDG PET after 1 cycle of chemotherapy is predictive of 18-mo outcome in patients with aggressive NHL and HD and may earlier identify patients who would benefit from more intensive treatment programs.

  • 373
  • PDF
Early therapy monitoring with FDG-PET in aggressive non-Hodgkin’s lymphoma and Hodgkin’s lymphoma
    T. TorizukaFumitoshi Nakamura Y. Ouchi

    Medicine

    European Journal of Nuclear Medicine and…

  • 2003

When performed early during chemotherapy, FDG-PET may be predictive of clinical outcome and allows differentiation of responders from non-responders in cases of aggressive lymphoma.

  • 110
Persistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin's lymphoma.
    G. JerusalemY. Beguin G. Fillet

    Medicine

    Haematologica

  • 2000

Persistent tumoral uptake after a few cycles of polychemotherapy is predictive of CR, PFS and OS in NHL and the sensitivity of qualitative (18)F-FDG PET imaging in identifying patients with a poor outcome was insufficient.

  • 213
18-FDG-PET as a Prognostic Indicator in the Treatment of Aggressive Non-Hodgkin's Lymphoma-Comparison with CT
    N. MikhaeelA. TimothyM. O'DohertyS. HainM. Maisey

    Medicine

  • 2000

FDG-PET is an accurate method of assessing remission and estimating prognosis following treatment of aggressive NHL, with positive and negative predictive accuracies of 100% and 82% respectively.

  • 256
Early restaging positron emission tomography with ( 18)F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin's lymphoma.
    K. SpaepenS. Stroobants G. Verhoef

    Medicine

    Annals of oncology : official journal of the…

  • 2002

Early restaging [(18)F]FDG-PET may be used to tailor induction chemotherapy in patients with aggressive NHL.

  • 421
  • PDF
[18F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in aggressive lymphoma: an early prognostic tool for predicting patient outcome.
    C. HaiounE. Itti M. Meignan

    Medicine

    Blood

  • 2005

Predictive value of "early PET" was observed in both the lower-risk and higher-risk groups, indicating prognostic independence from the IPI, and FDG-PET should be an early guide to first-line strategies in aggressive lymphoma.

  • 508
  • PDF
FDG-PET is Superior to Gallium Scintigraphy in Staging and More Sensitive in the Follow-up of Patients with de novo Hodgkin Lymphoma: A Blinded Comparison
    J. FriedbergA. Fischman A. D. Van den Abbeele

    Medicine

  • 2004

Diagnostic PET and gallium are largely concordant, with the exception of unique detection of splenic disease by PET, although more patients have persistently positive PET at the end of chemotherapy compared with gallium, although only half of these patients have relapsed.

  • 127
Positron emission tomography in non-Hodgkin's lymphoma: assessment of chemotherapy with fluorodeoxyglucose.
    Wolfgang RömerAxel-R. Hanauske M. Schwaiger

    Medicine

    Blood

  • 1998

Dynamic data acquisition combined with Patlak analysis of FDG kinetics may provide superior information in therapy monitoring andFDG uptake at 42 days after therapy was superior in prediction of long-term outcome over day 7 parameters.

  • 357

...

...

Related Papers

Showing 1 through 3 of 0 Related Papers

    [PDF] FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphoma. | Semantic Scholar (2025)
    Top Articles
    Latest Posts
    Recommended Articles
    Article information

    Author: Laurine Ryan

    Last Updated:

    Views: 5870

    Rating: 4.7 / 5 (57 voted)

    Reviews: 88% of readers found this page helpful

    Author information

    Name: Laurine Ryan

    Birthday: 1994-12-23

    Address: Suite 751 871 Lissette Throughway, West Kittie, NH 41603

    Phone: +2366831109631

    Job: Sales Producer

    Hobby: Creative writing, Motor sports, Do it yourself, Skateboarding, Coffee roasting, Calligraphy, Stand-up comedy

    Introduction: My name is Laurine Ryan, I am a adorable, fair, graceful, spotless, gorgeous, homely, cooperative person who loves writing and wants to share my knowledge and understanding with you.